Image Kyrapharm

Technology adapted to purification processes

High Performance Liquid Chromatography (HPLC) is an excellent tool for the separation, purification and isolation of substances from complex mixtures (chiral separation, isolation or elimination of impurities, concentration of plant extracts, etc.).
 
Kyrapharm has a wide range of stationary phases for the development and optimisation of purification processes:

  • Normal phase and reverse phase
  • Chiral phase
  • Size exclusion
  • Ion-exchange

Kyrapharm’s technology is adapted to:

  • Isolation of impurities
  • Resolution of racemates
  • Purification of plant extracts
  • Preparation of analytical standards
  • Etc.

Semi-preparative HPLC for impurity isolation
Semi-preparative HPLC for impurity isolation

The advantage of this technology is a simple and rapid extrapolation to the industrial scale: the process developed in the laboratory is directly scalable to industrial columns with very good reproducibility. The products obtained in a very short timeframe are of very high purity, an essential requirement for the pharmaceutical industry.

The Axyntis Group, an intermediate-sized company with estimated turnover of €100 M in 2014 and more than 420 employees, is a leading speciality chemicals company in France thanks to its GMP capabilities (700 m3). The group owns six sites (All’Chem in Montluçon, Centipharm in Grasse, Orgapharm in Pithiviers, Steiner in Saint Marcel and Synthexim in Calais, withtwo sites) and three R&D centres, all located in France. Its activities revolve around the life sciences (pharmacy, animal health, agrochemicals), dyes and speciality fine chemicals (electronics, photography, cosmetics, flavourings and perfumes, etc.)
www.axyntis.com

Orgapharm, located in Pithiviers, is a subsidiary of the Axyntis Group. The site employs 95 people and has a total reactor volume of 90 m3. It has been inspected by the Food and Drug Administration (last inspection in 2014), the French National Agency for Drug and Health Product Safety (ANSM) and is also ISO 14001 certified. Main Axyntis Research & Development centre is located at Orgapharm, together with a GMP pilot plant as well as multipurpose synthesis plants and an automated GMP crystallisation/finishing unit. The entire production cycle is covered, from the laboratory to industrial production, thereby enabling support for a project in its entirety.